Detalhe da pesquisa
1.
Feeding activates FGF15-SHP-TFEB-mediated lipophagy in the gut.
EMBO J
; 41(17): e109997, 2022 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35686465
2.
Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease.
J Biol Chem
; 299(8): 104946, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37348559
3.
MicroRNA-210 Promotes Bile Acid-Induced Cholestatic Liver Injury by Targeting Mixed-Lineage Leukemia-4 Methyltransferase in Mice.
Hepatology
; 71(6): 2118-2134, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31549733
4.
Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption.
Gastroenterology
; 156(4): 1052-1065, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30521806
5.
Transcriptional regulation of autophagy by an FXR-CREB axis.
Nature
; 516(7529): 108-11, 2014 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25383523
6.
Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3.
J Biol Chem
; 292(42): 17312-17323, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28808064
7.
Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
Hepatology
; 62(1): 220-31, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25545350
8.
Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor ß-Klotho.
Proc Natl Acad Sci U S A
; 109(40): 16137-42, 2012 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22988100
9.
Bile acid signal-induced phosphorylation of small heterodimer partner by protein kinase Cζ is critical for epigenomic regulation of liver metabolic genes.
J Biol Chem
; 288(32): 23252-63, 2013 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-23824184
10.
Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice.
Hepatology
; 56(1): 108-17, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22278336
11.
Paradoxical feeding activation of gut lipophagy by FGF15/FGF19-NR0B2/SHP-TFEB.
Autophagy
; 19(2): 742-743, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35913833
12.
Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice.
Mol Metab
; 66: 101603, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36126896
13.
Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver.
Diabetes
; 70(3): 733-744, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33328206
14.
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Nat Commun
; 11(1): 5969, 2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33235221
15.
Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase.
Nat Commun
; 11(1): 807, 2020 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32042044
16.
Fasting-induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid ß-oxidation.
J Clin Invest
; 128(7): 3144-3159, 2018 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29911994
17.
AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.
Nat Commun
; 9(1): 540, 2018 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29416063
18.
Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver.
Mol Cell Biol
; 37(15)2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28533219
19.
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of ß-Klotho.
Mol Endocrinol
; 30(1): 92-103, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26505219
20.
Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2.
Genome Biol
; 16: 268, 2015 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26634251